The unexpected guest: Cytotoxic, pseudolymphoma‐like reaction at the site of primary cutaneous follicle centre B‐cell lymphoma in a patient receiving secukinumab for psoriasis

Journal of the European Academy of Dermatology and VenereologyEarly View LETTER TO THE EDITOR The unexpected guest: Cytotoxic, pseudolymphoma-like reaction at the site of primary cutaneous follicle centre B-cell lymphoma in a patient receiving secukinumab for psoriasis C. Pescia, Corresponding Author C. Pescia [email protected] orcid.org/0000-0003-0657-506X Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Correspondence C. Pescia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. Email: [email protected]Search for more papers by this authorG. Pini, G. Pini Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalySearch for more papers by this authorS. Tabano, S. Tabano Medical Genetics Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Pathophysiology and Transplantation, University of Milan, Milan, ItalySearch for more papers by this authorE. Berti, E. Berti Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalySearch for more papers by this authorS. Alberti Violetti, S. Alberti Violetti Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalySearch for more papers by this authorG. A. Croci, G. A. Croci orcid.org/0000-0001-5979-7841 Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Pathophysiology and Transplantation, University of Milan, Milan, ItalySearch for more papers by this author C. Pescia, Corresponding Author C. Pescia [email protected] orcid.org/0000-0003-0657-506X Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Correspondence C. Pescia, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. Email: [email protected]Search for more papers by this authorG. Pini, G. Pini Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalySearch for more papers by this authorS. Tabano, S. Tabano Medical Genetics Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Pathophysiology and Transplantation, University of Milan, Milan, ItalySearch for more papers by this authorE. Berti, E. Berti Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalySearch for more papers by this authorS. Alberti Violetti, S. Alberti Violetti Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalySearch for more papers by this authorG. A. Croci, G. A. Croci orcid.org/0000-0001-5979-7841 Division of Pathology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy Department of Pathophysiology and Transplantation, University of Milan, Milan, ItalySearch for more papers by this author First published: 09 February 2024 https://doi.org/10.1111/jdv.19845Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat Open Research DATA AVAILABILITY STATEMENT All data are discussed in the manuscript. ETHICS STATEMENT The patient in this manuscript has given written informed consent to publication of the case details. REFERENCES 1Louissaint A, Sander CA, Santucci M, Vergier B, Willemze R, Pimpinelli N. Primary cutaneous follicle centre lymphoma. In: WHO Classification of Tumours Editorial Board, editor. Skin tumours. 5th ed. Vol. 12. Lyon, France: International Agency for Research on Cancer; 2023; forthcoming. (WHO classification of tumours series). Available from: https://publications.iarc.fr Google Scholar 2Wilcox RA. Cutaneous B-cell lymphomas: 2019 update on diagnosis, risk stratification, and management. Am J Hematol. 2018; 93(11): 1427–1430. 10.1002/ajh.25224 PubMedWeb of Science®Google Scholar 3Schultze JL, Seamon MJ, Michalak S, Gribben JG, Nadler LM. Autologous tumor infiltrating T cells cytotoxic for follicular lymphoma cells can be expanded in vitro. Blood. 1997; 89(10): 3806–3816. 10.1182/blood.V89.10.3806 CASPubMedWeb of Science®Google Scholar 4Mitteldorf C, Kempf W. Cutaneous pseudolymphoma-a review on the spectrum and a proposal for a new classification. J Cutan Pathol. 2020; 47(1): 76–97. 10.1111/cup.13532 PubMedWeb of Science®Google Scholar 5Pellegrini C, Esposito M, Rossi E, Gisondi P, Piaserico S, Dapavo P, et al. Secukinumab in patients with psoriasis and a personal history of malignancy: a multicenter real-life observational study. Dermatol Ther. 2022; 12(11): 2613–2626. 10.1007/s13555-022-00797-9 Google Scholar 6Lebwohl M, Deodhar A, Griffiths CEM, Menter MA, Poddubnyy D, Bao W, et al. The risk of malignancy in patients with secukinumab-treated psoriasis, psoriatic arthritis and ankylosing spondylitis: analysis of clinical trial and postmarketing surveillance data with up to five years of follow-up. Br J Dermatol. 2021; 185(5): 935–944. 10.1111/bjd.20136 CASPubMedWeb of Science®Google Scholar 7Cranwell WC, Doolan BJ, Radulski B, Nicolopoulos J, Dolianitis C. Pseudolymphoma induced by secukinumab for treatment of chronic plaque psoriasis. Australas J Dermatol. 2019; 60(3): e246–e248. 10.1111/ajd.13009 PubMedWeb of Science®Google Scholar 8Liang J, Zhang S, Li Q, Yu Y, Chen X, Zhang X. Review of secukinumab-induced adverse events of special interest and its potential pathogenesis. Dermatol Ther. 2022; 35(8):e15599. 10.1111/dth.15599 CASPubMedWeb of Science®Google Scholar 9Menguy S, Prochazkova-Carlotti M, Azzi-Martin L, Ferté T, Bresson-Bepoldin L, Rey C, et al. Proliferative tumor-infiltrating lymphocytes' abundance within the microenvironment impacts clinical outcome in cutaneous B-cell lymphomas. J Invest Dermatol. 2023; 143(1): 124–133.e3. 10.1016/j.jid.2022.06.027 CASPubMedWeb of Science®Google Scholar 10Laurent C, Müller S, Do C, Al-Saati T, Allart S, Larocca LM, et al. Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study. Blood. 2011; 118(20): 5371–5379. 10.1182/blood-2011-04-345777 CASPubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation