Worsening heart failure comes into focus, chronic heart failure takes a backseat

European Journal of Heart FailureEarly View Invited Editorial Worsening heart failure comes into focus, chronic heart failure takes a backseat Maribel González-Del-Hoyo, Maribel González-Del-Hoyo orcid.org/0000-0003-0587-050X Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSearch for more papers by this authorXavier Rossello, Corresponding Author Xavier Rossello [email protected] orcid.org/0000-0001-6783-8463 Cardiology Department, Hospital Universitari Son Espases, Palma, Spain Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain Facultat de Medicina, Universitat de les Illes Balears (UIB), Palma, Spain Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain Corresponding author. Cardiology Department, Hospital Universitari Son Espases-IDISBA, Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain. Email: [email protected]Search for more papers by this author Maribel González-Del-Hoyo, Maribel González-Del-Hoyo orcid.org/0000-0003-0587-050X Department of Cardiology, University Heart Center, University Hospital Zurich, University of Zurich, Zurich, SwitzerlandSearch for more papers by this authorXavier Rossello, Corresponding Author Xavier Rossello [email protected] orcid.org/0000-0001-6783-8463 Cardiology Department, Hospital Universitari Son Espases, Palma, Spain Health Research Institute of the Balearic Islands (IdISBa), Palma, Spain Facultat de Medicina, Universitat de les Illes Balears (UIB), Palma, Spain Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain Corresponding author. Cardiology Department, Hospital Universitari Son Espases-IDISBA, Carretera de Valldemossa, 79, 07120 Palma, Illes Balears, Spain. Email: [email protected]Search for more papers by this author First published: 21 January 2024 https://doi.org/10.1002/ejhf.3143 The opinions expressed in this article are not necessarily those of the Editors of the European Journal of Heart Failure or of the European Society of Cardiology. doi: 10.1002/ejhf.3048. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Greene SJ, Fonarow GC, Butler J. Risk profiles in heart failure: Baseline, residual, worsening, and advanced heart failure risk. Circ Heart Fail 2020; 13:e007132. https://doi.org/10.1161/CIRCHEARTFAILURE.120.007132 10.1161/CIRCHEARTFAILURE.120.007132 PubMedWeb of Science®Google Scholar 2Metra M, Tomasoni D, Adamo M, Bayes-Genis A, Filippatos G, Abdelhamid M, et al. Worsening of chronic heart failure: Definition, epidemiology, management and prevention. A clinical consensus statement by the Heart Failure Association of the European Society of Cardiology. Eur J Heart Fail 2023; 25: 776–791. https://doi.org/10.1002/ejhf.2874 10.1002/ejhf.2874 PubMedWeb of Science®Google Scholar 3Greene SJ, Bauersachs J, Brugts JJ, Ezekowitz JA, Lam CSP, Lund LH, et al. Worsening heart failure: Nomenclature, epidemiology, and future directions. J Am Coll Cardiol 2023; 81: 413–424. https://doi.org/10.1016/j.jacc.2022.11.023 10.1016/j.jacc.2022.11.023 PubMedWeb of Science®Google Scholar 4Shakoor A, Abou Kamar S, Malgie J, Kardys I, Schaap J, de Boer RA, et al. The different risk of new-onset, chronic, worsening, and advanced heart failure: A systematic review and meta-regression analysis. Eur J Heart Fail. https://doi.org/10.1002/ejhf.3048 Published online ahead of print 12/10/23. 10.1002/ejhf.3048 Web of Science®Google Scholar 5Rossello X, González-Del-Hoyo M. Survival analyses in cardiovascular research, part II: Statistical methods in challenging situations. Rev Esp Cardiol (Engl Ed) 2022; 75: 77–85. https://doi.org/10.1016/j.rec.2021.07.001 10.1016/j.recesp.2021.06.027 PubMedGoogle Scholar 6Greene SJ, Triana TS, Ionescu-Ittu R, Shi S, Guérin A, DeSouza MM, et al. Patients hospitalized for de novo versus worsening chronic heart failure in the United States. J Am Coll Cardiol 2021; 77: 1023–1025. https://doi.org/10.1016/j.jacc.2020.12.026 10.1016/j.jacc.2020.12.026 PubMedWeb of Science®Google Scholar 7Greene SJ, Bauersachs J, Brugts JJ, Ezekowitz JA, Filippatos G, Gustafsson F, et al. Management of worsening heart failure with reduced ejection fraction: JACC focus seminar 3/3. J Am Coll Cardiol 2023; 82: 559–571. https://doi.org/10.1016/j.jacc.2023.04.057 10.1016/j.jacc.2023.04.057 PubMedWeb of Science®Google Scholar 8Lupón J, Gavidia-Bovadilla G, Ferrer E, de Antonio M, Perera-Lluna A, López-Ayerbe J, et al. Dynamic trajectories of left ventricular ejection fraction in heart failure. J Am Coll Cardiol 2018; 72: 591–601. https://doi.org/10.1016/j.jacc.2018.05.042 10.1016/j.jacc.2018.05.042 PubMedWeb of Science®Google Scholar 9Clarke CL, Grunwald GK, Allen LA, Barón AE, Peterson PN, Brand DW, et al. Natural history of left ventricular ejection fraction in patients with heart failure. Circ Cardiovasc Qual Outcomes 2013; 6: 680–686. https://doi.org/10.1161/CIRCOUTCOMES.111.000045 10.1161/CIRCOUTCOMES.111.000045 PubMedWeb of Science®Google Scholar 10Skali H, Dwyer EM, Goldstein R, Haigney M, Krone R, Kukin M, et al. Prognosis and response to therapy of first inpatient and outpatient heart failure event in a heart failure clinical trial: MADIT-CRT. Eur J Heart Fail 2014; 16: 560–565. https://doi.org/10.1002/ejhf.71 10.1002/ejhf.71 CASPubMedWeb of Science®Google Scholar 11Parikh RV, Go AS, Bhatt AS, Tan TC, Allen AR, Feng KY, et al. Developing clinical risk prediction models for worsening heart failure events and death by left ventricular ejection fraction. J Am Heart Assoc 2023; 12:e029736. https://doi.org/10.1161/JAHA.122.029736 10.1161/JAHA.122.029736 PubMedWeb of Science®Google Scholar 12Bozkurt B, Coats AJS, Tsutsui H, Abdelhamid CM, Adamopoulos S, Albert N, et al. Universal definition and classification of heart failure: A report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure: Endorsed by the Canadian Heart Failure Society, Heart Failure Association of India, Cardiac Society of Australia and New Zealand, and Chinese Heart Failure Association. Eur J Heart Fail 2021; 23: 352–380. https://doi.org/10.1002/ejhf.2115 10.1002/ejhf.2115 PubMedWeb of Science®Google Scholar 13Hicks KA, Mahaffey KW, Mehran R, Nissen SE, Wiviott SD, Dunn B, et al. 2017 Cardiovascular and stroke endpoint definitions for clinical trials. J Am Coll Cardiol 2018; 71: 1021–1034. https://doi.org/10.1016/j.jacc.2017.12.048 10.1016/j.jacc.2017.12.048 PubMedWeb of Science®Google Scholar 14Docherty KF, Jhund PS, Anand I, Bengtsson O, Böhm M, de Boer RA, et al. Effect of dapagliflozin on outpatient worsening of patients with heart failure and reduced ejection fraction: A prespecified analysis of DAPA-HF. Circulation 2020; 142: 1623–1632. https://doi.org/10.1161/CIRCULATIONAHA.120.047480 10.1161/CIRCULATIONAHA.120.047480 CASPubMedWeb of Science®Google Scholar 15Madelaire C, Gustafsson F, Stevenson LW, Kristensen SL, Køber L, Andersen J, et al. One-year mortality after intensification of outpatient diuretic therapy. J Am Heart Assoc 2020; 9:e016010. https://doi.org/10.1161/JAHA.119.016010 10.1161/JAHA.119.016010 PubMedWeb of Science®Google Scholar 16Ferreira JP, Metra M, Mordi I, Gregson J, Ter Maaten JM, Tromp J, et al. Heart failure in the outpatient versus inpatient setting: Findings from the BIOSTAT-CHF study. Eur J Heart Fail 2019; 21: 112–120. https://doi.org/10.1002/ejhf.1323 10.1002/ejhf.1323 CASPubMedWeb of Science®Google Scholar 17Rosano GMC, Savarese G. Implementing an earlier and more intensive follow-up in acute heart failure: The STRONG-HF and COACH trials. Nat Rev Cardiol 2023; 20: 213–214. https://doi.org/10.1038/s41569-023-00841-x 10.1038/s41569-023-00841-x PubMedWeb of Science®Google Scholar 18Girerd N, Mewton N, Tartière J, Guijarro D, Jourdain P, Damy T, et al. Practical outpatient management of worsening chronic heart failure. Eur J Heart Fail 2022; 24: 750–761. https://doi.org/10.1002/ejhf.2503 10.1002/ejhf.2503 PubMedWeb of Science®Google Scholar 19Greene SJ, Goto D, Wang D, Hilkert R, Lautsch D, Fonarow GC. Outpatient versus inpatient intravenous diuretic therapy for heart failure in the United States. Eur J Heart Fail 2022; 24: 2199–2202. https://doi.org/10.1002/ejhf.2727 10.1002/ejhf.2727 PubMedWeb of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation