化学
激进的
亚胺
电泳剂
亲核细胞
基础(拓扑)
组合化学
对偶(序理论)
基质(水族馆)
光化学
有机化学
催化作用
数学分析
地质学
离散数学
海洋学
数学
作者
Runwei Jiao,Xuhong Ren,Xiheng Li,Shitao Sun,Hai‐Liang Zhu,Bin Lin,Hui‐Ming Hua,Dahong Li,Xinhua He
标识
DOI:10.1021/acs.orglett.3c03490
摘要
Herein, we present a green scheme for the divergent synthesis of two polysubstituted quinolines from a singular substrate via exploiting free-radical duality. Photocatalytically generated imine radicals produce 3,4-disubstituted quinolines via a novel rearrangement in the presence of an inorganic base. Alternatively, they react in the presence of an organic base to furnish 2,3-disubstituted quinolines. Mechanism studies support the hypothesis that the electrophilic/nucleophilic bias of free radicals can be adjusted by altering the reaction conditions.
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