Alternative approaches for alcohol septal ablation in hypertrophic cardiomyopathy: the call for a personalized treatment

Hypertrophic cardiomyopathy (HCM) is a relatively common genetic condition characterized by increased thickness of the left ventricular wall1,2. The presence of left ventricular outflow tract (LVOT) obstruction is a defining feature of HCM and constitutes a key element in both the diagnosis and the management of the disease3. LVOT obstruction in HCM is primarily attributed to the systolic anterior movement (SAM) of elongated mitral valve leaflets, which come into contact with the septum at the subaortic level.