Gut microbiota-derived xanthohumol protects against heatstroke by inhibiting macrophage pyroptosis in mice

Our findings suggest that gut microbiota and their associated metabolites play a critical role in heatstroke-induced organ injury. We provide evidence that XN acts as a novel hnRNPK inhibitor, effectively mitigating heatstroke-induced organ injury. Furthermore, gut microbiota-derived XN alleviates heatstroke-induced organ injury by suppressing hnRNPK-dependent macrophage pyroptosis, thereby identifying XN as a promising preventive strategy for heatstroke.