Developing chemical reprogramming strategies of non-hepatocytes for liver regeneration

Chemical reprogramming induces the reprogramming of non-hepatic cells into hepatocyte-like cells through the precise regulation of cellular signaling pathways and epigenetic modifications by small molecules, thereby achieving cellular composition remodeling in injured livers. Current liver regeneration strategies rely on the modulation of endogenous regenerative capacity and cell-based therapies; thus, elucidating the regenerative and reparative roles of chemical reprogramming in liver injury is imperative. Addressing the inherent challenges of chemical reprogramming in hepatic regeneration is also underscored.