Type 2 Uveal Effusion Syndrome with Psoriasis Vulgaris: A Case Report

To report the case of uveal effusion syndrome (UES) in a 35-year-old woman with psoriasis vulgaris, emphasizing scleral pathology and systemic inflammatory contributions mediated by proteomic alterations. Medical history, clinical findings and treatment were reviewed, along with histopathological and proteomic analysis. A 35-year-old woman presented with retinal and choroidal detachments in the left eye and scleral thickening (3 mm vs. normal 1 mm). Concurrently, her psoriasis symptoms worsened. Histology revealed collagen disorganization and extracellular matrix remodeling in the sclera, accompanied by elevated inflammatory factors (e.g. MCP-4, RANTES, Fractalkine). Treatment included partial sclerotomy, leading to resolution of detachments and improved visual acuity. Systemic inflammation associated with psoriasis may contribute to UES pathogenesis. Dermatologists should refer psoriasis patients for ophthalmologic examinations, while ophthalmologists should be aware of underlying health conditions when treating UES.