色氨酸
化学
化学改性
吲哚试验
部分
翻译后修饰
生物化学
肽
化学生物学
氨基酸残基
肽序列
组合化学
立体化学
氨基酸
酶
基因
作者
Jin-Jian Hu,Peng He,Yanmei Li
摘要
Chemical protein modifications facilitate the investigation of natural posttranslational protein modifications and allow the design of proteins with new functions. Proteins can be modified at a late stage on amino acid side chains by chemical methods. The indole moiety of tryptophan residues is an emerging target of such chemical modification strategies because of its unique reactivity and low abundance. This review provides an overview of the recently developed methods of tryptophan modification at the peptide and protein levels.
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