Wound healing is a highly ordered biological process involving a variety of cells, fluids, and molecules. Any obstacles in the link may cause poor wound healing and even the formation of chronic wounds. In recent years, more and more studies have reported that hydrogen peroxide plays an important role in wound healing and throughout the whole process of wound healing. This article reviews the research progress of hydrogen peroxide and literatures in the related fields to provide new ideas and clues for promoting the basic and clinical research of wound healing.