Metabolism amelioration of Dendrobium officinale polysaccharide on type II diabetic rats

Diabetes is a metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion and/or action. The anti-diabetic effects of polysaccharide from Dendrobium officinale stem (DOP) on type II diabetic rats was evaluated in this study. Treatment with DOP significantly decreased the concentrations of fasting blood glucose, insulin, glycated serum protein, serum lipids (TC, TG, LDL-c, NEFA), and increased the concentration of HDL-c, compared with the untreated diabetic rats. In addition, DOP treatment alleviated the oxidative stress injury by increasing the activity of superoxide dismutase and total antioxidant capacity, as well as decreased the level of malonaldehyde. Histopathological analysis revealed that DOP has protective effects on type II diabetes induced pancreatic injury. Serum metabolomics and lipidomics analysis also found DOP treatment could decrease serum fatty acids, glycerolipids, sphingolipids, phospholipids and bile acids, and alleviate the metabolism disorders of lipid, bile acids and amino acids.