化脓性汗腺炎
真皮
表皮(动物学)
顶泌
生物
上皮
干细胞
病理
细胞因子
转录组
免疫系统
细胞
细胞生物学
疾病
医学
免疫学
解剖
基因
基因表达
遗传学
作者
M. Marohn,Meng-Ju Lin,Weifang Yu,Ciara Mae Mendoza,Juliana Remark,Alireza Khodadadi‐Jamayran,Ernest S. Chiu,Catherine P. Lu
标识
DOI:10.1101/2020.04.21.053611
摘要
Abstract Hidradenitis suppurativa (HS) is a severe chronic inflammatory skin disease affecting human apocrine sweat gland-bearing skin regions. One unique feature of HS is the development of keratinized sinus tracts that grow extensively deep in the dermis and are highly immunogenic. Here, we demonstrated that the stem cell fate infidelity exists in the HS sinus tracts, which exhibit features of both surface epidermis and appendages. Using single cell transcriptome analyses, we finely dissected different compartments of the HS epithelium and identified their respective changes in cytokine expression during disease progression and the critical interactions with the immune cells. Together, our work provides advanced understanding of the pathological epidermal remodeling and important implications for HS therapeutics.
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