医学
转移瘤切除术
结直肠癌
内科学
多元分析
体质指数
单变量分析
探索性分析
肿瘤科
回顾性队列研究
队列
胃肠病学
癌症
计算机科学
数据科学
作者
Debora Basile,Michele Bartoletti,Maurizio Polano,L. Bortot,Lorenzo Gerratana,Paola Di Nardo,M.O. Borghi,Valentina Fanotto,Giacomo Pelizzari,C. Lisanti,Mattia Garutti,Silvia Buriolla,Elena Ongaro,Eva Andreuzzi,Marcella Montico,Luca Balestreri,Gianmaria Miolo,Giuseppe Toffoli,Giuseppe Aprile,Fabio Puglisi,Angela Buonadonna
标识
DOI:10.1016/j.clnu.2020.05.019
摘要
Background Body composition, has been established as a risk factor for colorectal cancer diagnosis and disease progression. Aim of this study was to investigate the prognostic role of adiposity, especially visceral fat (VAT), in patients (pts) with metastatic colorectal cancer (MCRC). Material and methods A retrospective cohort of 71 MCRC pts treated between 2013 and 2017 was evaluated. VAT was measured as cross-sectional (cm2) area at the L3 level divided by the square of the height (m2). A ROC analysis was performed to define a prognostic threshold according to VAT. Results Before first-line therapy start, 40 pts (56%) had a body mass index (BMI) > 25 kg/m2. The obtained cut-off value for VAT was 44. Median OS was 30.97 months. At univariate analysis, primary tumor resection (HR 0.40, p = 0.029), VAT>44 (HR 2.85, p = 0.011) and metastasectomy (HR 0.22, p = 0.005) were significantly associated with OS. By multivariate analysis, VAT>44 (HR 2.6; p = 0.020) and metastasectomy were still significantly associated with OS. Conclusion This exploratory study suggests a prognostic role for VAT in MCRC pts, with higher VAT values predicting worse outcome.
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