Clinical efficacy of natural formulated shampoo in subjects with dandruff and seborrheic dermatitis

Backgrounds and aims: Dandruff is a common scalp condition characterized by flakes, pruritus and sometimes mild erythema. Despite the development of several medical treatments, the number of men and women who suffer from Dandruff and Seborrheic Dermatitis is increasing. We searched for potential therapeutics among those plant extracts that have been used traditionally in oriental medicine for treating Dandruff (D) and Seborrheic Dermatitis (SD). Patients & Methods: 120 volunteers, who suffered from dandruff, were recruited into the study in 3 groups. The first group used Cepigene shampoo, the second group used Ketoconazole shampoo and the third group used vehicle. The samples were also cultured for fungi detection. For isolating the fungi and evaluating the rate of Dandruff and Seborrheic dermatitis, the subjects were sampled from their scalp in zero day of the study. Trypan blue assay was used to study the antifungal effects of cepigen and ketoconasole.