Tiroglobulina y sus limitaciones en el seguimiento del carcinoma diferenciado del tiroides

Thyroid carcinoma is the most prevalent endocrine tumor, andthe papillary carcinoma (PC) is the most common histological type. In the follow-up, afterthyroidectomy serum thyroglobulin (s-Tg) is used as a marker to evaluate recurrence of thyroidcarcinoma. In most cases, this parameter allows an adequate diagnosis, but occasionally s-Tgmay miss the detection of a recurrence. We report a 57 year-old female and a 36 year-old malesujected to a total thyroidectomy for a papillary thyroid carcinoma with intermediate and high-risk of recurrence. Both had a cervical recurrence without a concomitant increase in s-Tglevels. In both, Tg staining was positive in the tumor cells. These cases confirm that in thesepatients, the follow-up must be done with measurement of s-Tg and complementary diagnostictests (Rev Med Chile 2007; 135: 506-11).(