喹啉
抗菌剂
铜绿假单胞菌
化学
微生物学
抗氧化剂
生物
有机化学
抗氧化剂
细菌
遗传学
作者
Khomsan Supong,Chitti Thawai,Sumalee Supothina,Patchanee Auncharoen,Pattama Pittayakhajonwut
标识
DOI:10.1016/j.phytol.2016.07.007
摘要
Abstract Twelve 4-hydroxyquinoline derivatives ( 1 12 ) and three phenazine alkaloids ( 1315 ) have been isolated from Pseudomonas aeruginosa BCC76810. All these compounds, except compounds 6 , 7 , 9 , and 11 , are known. The new quinolines are 2-(( Z )-undec-4⿲-enyl)-4-hydroxyquinoline ( 6 ), 2-(3⿲-(2⿲-hexylcyclopropyl)propyl)-4-hydroxyquinoline ( 7 ), 2- n- octyl-4-hydroxyquinoline N -oxide ( 9 ), and 2-(( Z )-undec-4⿲-enyl)-4-hydroxyquinoline N -oxide ( 11 ). Their structures were elucidated based on the spectroscopic information, such as 1D, 2D NMR, UV, and HRESIMS data. 4-Hydroxyquinolines ( 1 6 ) and 4-hydroxyquinoline- N- oxides ( 8 11 ) exhibited antimalarial activity against Plasmodium falciparum , K1 strain (IC 50 0.252.07 μg/mL) with moderate to weak cytotoxicity against cancerous (KB, MCF-7, NCI-H187) and non-cancerous (Vero) cells. In addition, 4-hydroxyquinoline N -oxides also displayed anti- Bacillus cereus and antioxidant activities.
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