Four‐Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross‐Coupling for the Synthesis of Bis‐Heteroarenes

Abstract A series of stable phosphonium salts have been synthesized via a novel four‐component reaction of an arene nucleophile, 2‐heteroatom substituted aryl aldehyde, and phosphine in presence of an acid. The phosphonium salts thus obtained were utilized for the synthesis of a variety of bis‐heteroarenes, providing an efficient alternative method to the classical cross‐coupling strategies.