髓系白血病
癌症研究
骨髓增生异常综合症
白血病
髓样
生物
医学
骨髓
内科学
净现值1
作者
Justin C. Wheat,Ulrich Steidl
出处
期刊:Blood
[American Society of Hematology]
日期:2021-08-26
卷期号:138 (8): 625-636
被引量:2
标识
DOI:10.1182/blood.2019004261
摘要
Nongenetic heterogeneity, or gene expression stochasticity, is an important source of variability in biological systems. With the advent and improvement of single molecule resolution technologies, it has been shown that transcription dynamics and resultant transcript number fluctuations generate significant cell-to-cell variability that has important biological effects and may contribute substantially to both tissue homeostasis and disease. In this respect, the pathophysiology of stem cell-derived malignancies such as acute myeloid leukemia and myelodysplastic syndromes, which has historically been studied at the ensemble level, may require reevaluation. To that end, it is our aim in this review to highlight the results of recent single-molecule, biophysical, and systems studies of gene expression dynamics, with the explicit purpose of demonstrating how the insights from these basic science studies may help inform and progress the field of leukemia biology and, ultimately, research into novel therapies.
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