医学
内科学
糖尿病
内分泌学
极低密度脂蛋白
肠系膜
链脲佐菌素
安慰剂
肥胖
胆固醇
脂蛋白
外科
病理
替代医学
作者
Fernanda Rossi Paolillo,Thays Yara Teófilo Borges Campos,Carolina Álvarez,Marcela Sene-Fiorese,Vanderlei Salvador Bagnato,Ana Cláudia Garcia de Oliveira Duarte,Nivaldo Antônio Parizotto
标识
DOI:10.1002/jbio.202100109
摘要
Abstract Nowadays, the mesentery as a new organ was discovered. Mesenteric events may play an important role in the pathophysiology of several diseases. The aim of our study was investigate the synergic effects of ultrasound (US) and laser therapies on mesentery in obese‐hyperglycemic rats. The 25 male Wistar rats were randomized into five groups. Obese nondiabetic (OND) group: obese rats without diabetes and no treatment conditions; SHAM group: obese‐hyperglycemic rats treated with placebo; US group: obese‐hyperglycemic rats treated with US; LASER group: obese‐hyperglycemic rats treated with laser and; US+LASER group: obese‐hyperglycemic rats treated with US plus laser. An animal model of type 2 diabetes based on a hyperlipidemic diet combined with a low dose of streptozotocin was used in this study. Body mass and biochemical measurements were performed. GOT and GPT level showed a significant reduction in the treated groups than SHAM. The total cholesterol, triglycerides and very low‐density lipoprotein (VLDL) levels showed significantly lower values for the US+LASER group. There was also reduced risk of cardiovascular diseases evidenced by Castelli index in the treated groups than SHAM. This study showed that the US and laser treatment on mesentery resulted to an improvement in biochemical measurements of the obese‐hyperglycemic rats, especially the total cholesterol, triglycerides and VLDL levels.
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