立体化学
海洋真菌
真菌
化学
癌细胞系
细胞毒性T细胞
细胞毒性
二维核磁共振波谱
曲霉
生物
微生物学
癌细胞
体外
生物化学
癌症
植物
遗传学
作者
Jun Wu,Wang Fu-qian,Li He,Siyuan Zhou,Shoubao Wang,Jia Jia,Kui Hong,Yuanfeng Cai
标识
DOI:10.1080/14786419.2021.1998047
摘要
A new paraherquamide named aculeaquamide A (1) was isolated from an EtOAc extract of Aspergillus aculeatinus WHF0198 culture media together with five known compounds. The structures of the isolated compounds were elucidated by analysis of NMR and MS data, and the absolute configurations of compound 1 was confirmed by CD spectroscopic methods. All isolated compounds were evaluated for their cytotoxicity against three human cancer cell lines, Bel-7402, A549, and HCT-116. Compounds 1 and 2 showed cytotoxicity against Bel-7402 with IC50 values of 3.3 and 1.9 μM, respectively.
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