The “magic bullet” by Paul Ehrlich is a chemotherapeutic, which can precisely locate and destroy tumor cells. For over 100 years, a great number of approaches have been developed for targeted delivery of toxins. Nevertheless, the progress in the battle with cancer is moderate. In reality, the magic bullet is unable to destroy cancer cells with 100% efficacy. However, cancer cells are neither an optimal nor the only possible target. The magic bullet needs a “magic target”.