氧化应激
活性氧
氧化还原
百草枯
秀丽隐杆线虫
细胞生物学
刺激
老化
化学
生物物理学
生物
生物化学
神经科学
遗传学
基因
有机化学
作者
Jiao Meng,Zhenyu Lv,Yuanyuan Wang,Chang Chen
标识
DOI:10.1016/j.freeradbiomed.2021.11.018
摘要
Reactive oxygen species (ROS) play a dual role since they can be either beneficial or harmful to living systems. With increasing ROS concentrations, the roles of ROS change from advantageous to detrimental. There seems to be a concentration threshold that determines the transition from their advantageous to detrimental effects. If we purposefully increase the threshold, that is, increase the range of ROS that plays an advantageous role, it should be beneficial for individuals. To test this hypothesis, in C. elegans, the effects of oxidative challenge induced by different concentrations of paraquat (PQ) on nematode lifespan were evaluated. We found that there is a maximum level below which redox stress has benefits and named this threshold as "Redox-stress Signaling Threshold (RST)". Furthermore, we found that starvation (or heat stress or exercise) stimuli at early stage in C. elegans could increase the RST, indicating that this value is not fixed and can be increased by the adaptive response. More intriguingly, we found that increasing RST could improve Redox-stress Response Capacity (RRC) and healthspan, suggesting that increasing the RST value through early stimulation will be an effective strategy to delay aging.
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