纤颤
生物利用度
化学
淀粉样蛋白(真菌学)
生物物理学
多酚
纤维
胰岛素
药品
溶解度
药理学
生物化学
生物
有机化学
内科学
医学
无机化学
抗氧化剂
心房颤动
作者
Mohammad Ramezani,Maryam Dehghan Hesami,Yasin Rafiei,Ebrahim Rostampour Ghareghozloo,Ali Akbar Meratan,Nasser Nikfarjam
出处
期刊:ACS applied bio materials
[American Chemical Society]
日期:2021-03-15
卷期号:4 (4): 3547-3560
被引量:17
标识
DOI:10.1021/acsabm.1c00068
摘要
Among common strategies for amyloid fibrillation inhibition, the use of naturally occurring polyphenols as an efficient therapeutic approach has attracted a growing body of attention. However, the poor water solubility and low bioavailability of these compounds have greatly restricted their clinical application in amyloid-related diseases. Thus, different types of formulations have been developed to overcome these limitations; among them, nanonization appears to be one of the most notable approaches. Herein, we show that the polyphenolic fraction of propolis (PFP), in the nanosheet form (PFP nanosheet), exhibits an improved capacity for amyloid fibrillation inhibition as well as clearance of preformed fibrils of bovine insulin. This increased efficiency is suggested to be related to the aqueous solubility and surface area enhancement as well as surface modifications upon undergoing the nanonization process, which can lead to strong binding with and trapping of protein at the surface of the nanosheets. On the basis of thioflavin T results, it is suggested that although PFP may modulate the fibrillation process via shortening of the lag phase, prolongation of the nucleation phase through interaction with and stabilizing monomeric species is the mechanism of action of PFP nanosheets. We propose that nanonization of natural small molecules can be considered as a powerful approach to improve their anti-amyloidogenic properties and overcome obstacles originating from poor water solubility and low bioavailability of drug candidates relating to neurodegenerative diseases. Taken together, the obtained results may suggest PFP nanosheets as a potential candidate for use against neurological disorders.
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