癫痫
神经炎症
小胶质细胞
星形胶质细胞
促炎细胞因子
神经科学
肿瘤坏死因子α
谷氨酸受体
细胞因子
调节器
神经退行性变
信号转导
生物
受体
中枢神经系统
细胞生物学
免疫学
医学
炎症
疾病
内科学
生物化学
基因
作者
Rui Chen,Guofang Xue,Christian Hölscher
标识
DOI:10.1186/s42494-021-00059-9
摘要
Abstract Epilepsy is a common disease in the central nervous system. There is growing evidence that epilepsy is associated with glial cells, including astrocytes. Tumor necrosis factor α (TNFα) is a “master regulator” of proinflammatory cytokine production and is secreted by microglia and astrocytes. TNFα secreted by microglia can activate astrocytes. Additionally, TNFα can regulate neuron activity and induce epilepsy by increasing the glutamate release, reducing the expression of γ-aminobutyric acid, inducing neuroinflammation and affecting the synaptic function in astrocytes. This review summarizes the signaling pathways and receptors of TNFα acting on astrocytes that are related to epilepsy and provides insights into the potential therapeutic strategies of epilepsy for clinical practice.
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