[P4–153]: INCIDENCE AND FACTORS ASSOCIATED WITH THE ONSET OF POST‐DURAL PUNCTURE HEADACHE: EXPERIENCE FROM THE JAPANESE ADNI AND REVIEW OF LITERATURE

High diagnostic accuracy of cerebral spinal fluid (CSF) biomarkers, such as Aβ1–42, total tau and phosphorylated tau, has been shown for Alzheimer's disease (AD). As utility of these biomarkers is recognized, collection of CSF by lumbar puncture is increasingly performed in memory clinics. Post-dural puncture headache (PDPH) is the most common adverse event associated with lumbar puncture. We investigated incidence of PDPH in Japanese AD Neuroimaging Initiative (J-ADNI) cohorts, and reviewed literature regarding incidence of PDPH in memory clinic populations to determine factors associated with the onset of PDPH, such as age, cognitive status, history of headache, puncture position, needle type, needle size, collected CSF volume, and rest after LP. Of the 303 LP procedures in J-ADNI cohorts, PDPH occurred in 8 subjects (incidence 2.6%). Of these, two cases were hospitalized, but their symptoms relieved without blood patch treatment. Incidence of PDPH in 9 previous reports ranged from 0.9 to 20.3%. Review of literature revealed that older age (4 of 7 reports) and atraumatic needles (3 of 3 reports) reduced incidence of PDPH in memory clinic populations, whereas rest after LP had no effect (0 of 3 reports). The other factors were inconsistent among the studies. LP appears to be a relatively safe procedure for the differential diagnosis of dementia for the elderly in clinical research and memory clinic setting. Meanwhile, it is recommended to use atraumatic needles to reduce incidence of PDPH when performing LP for younger subjects.