动态光散射
核化学
傅里叶变换红外光谱
人参皂甙
纳米颗粒
选区衍射
胶体金
材料科学
细胞凋亡
细胞毒性
A549电池
化学
透射电子显微镜
分析化学(期刊)
人参
纳米技术
体外
生物化学
色谱法
医学
化学工程
病理
工程类
替代医学
作者
Yeon-Ju Kim,Haribalan Perumalsamy,Josua Markus,Sri Renukadevi Balusamy,Chao Wang,Seong Ho Kang,Seung‐Ah Lee,Sang Yong Park,Sung Hoon Kim,Verónica Castro-Aceituno,Seung Hyun Kim,Deok Chun Yang
标识
DOI:10.1080/21691401.2018.1541900
摘要
We report a non-covalent loading of ginsenoside compound K (CK) onto our previously reported gold nanoparticles (DCY51T-AuCKNps) through one-pot biosynthesis using a probiotic Lactobacillus kimchicus DCY51T isolated from Korean kimchi. The ginsenoside-loaded gold nanoparticles were characterized by various analytical and spectroscopic techniques such as field emission transmission electron microscopy (FE-TEM), energy-dispersive X-ray (EDX) spectroscopy, elemental mapping, X-ray powder diffraction (XRD), selected area electron diffraction (SAED), Fourier-transform infrared (FTIR) spectroscopy and dynamic light scattering (DLS). Furthermore, drug loading was also determined by liquid chromatography-mass spectrometry (LC-MS). In addition, DCY51T-AuNps and DCY51T-AuCKNps were resistant to aggregation caused by pH variation or a high ionic strength environment. Cell-based study confirmed that DCY51T-AuCKNps exhibited slightly higher cytotoxicity compared to ginsenoside CK treatment in A549 cells (human lung adenocarcinoma cell line) and HT29 (human colorectal adenocarcinoma cell line). Upon laser treatment, DCY51T-AuCKNps showed enhanced cell apoptosis in A549, HT29 and AGS cells (human stomach gastric adenocarcinoma cell line) compared with only DCY51T-AuCKNps treated cells. In conclusion, this preliminary study identified that DCY51T-AuCKNps act as a potent photothermal therapy agents with synergistic chemotherapeutic effects for the treatment of cancer.
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