心房颤动
医学
心力衰竭
心脏病学
心房颤动的处理
重症监护医学
心脏再同步化治疗
导管消融
内科学
随机对照试验
指南
射血分数
病理
作者
Matthew A. Carlisle,Marat Fudim,Adam D. DeVore,Jonathan P. Piccini
标识
DOI:10.1016/j.jchf.2019.03.005
摘要
Heart failure and atrial fibrillation are 2 common cardiovascular disorders that frequently complicate one another and exert a significant detrimental effect on cardiovascular health and well-being. Both heart failure and atrial fibrillation continue to increase in prevalence as the risk factors underlying each condition become more common. This review encompasses what is currently known about the epidemiology and pathophysiology of these comorbidities along with incorporation of landmark trials that have contributed to current guidelines. The focus is on clinically relevant considerations, including the contribution of inflammation in the pathophysiology of atrial fibrillation and heart failure. We explore the emerging role of catheter ablation relative to medical therapy in the management of heart failure with reduced ejection fraction, along with indications for biventricular pacing modalities in cardiac resynchronization therapy. We discuss current guideline-directed therapies and how practice models and national recommendations will likely change based on the most recent randomized controlled trials.
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