Toward an Asymmetric Synthesis of Bistramide K

The bistramides family has shown antitumoral activity. More specifically bistramide K exhibits lower toxicity than its congeners. In this work, we describe a highly stereoselective and convergent synthesis of two building blocks of the marine metabolite bistramide K. Thus, we report the synthesis of fragments C1–C18 ( 89 ) and C19–C40 ( 81 ) of bistramide K. As a challenge, we have used nonracemic methyl p ‐tolyl sulfoxide as unique source of chirality for the elaboration of all stereogenic centers of the natural compound.