自愈水凝胶
乙烯醇
材料科学
生物相容性
化学工程
琼脂糖
聚乙烯醇
复合材料
肿胀 的
高分子化学
聚合物
化学
色谱法
工程类
冶金
作者
Sen Wang,Heng Li,Zhiming Qi,Menghong Yin,Chengwei Wu,Wei Zhang
出处
期刊:Lecture notes in mechanical engineering
日期:2019-07-05
卷期号:: 743-749
被引量:2
标识
DOI:10.1007/978-981-13-8331-1_58
摘要
Poly (vinyl alcohol) (PVA) hydrogels are widely used in biomimetic cartilage materials for its good biocompatibility and super shock absorbing properties. However, the small pore size, in general, a few micrometers, of pure PVA hydrogels prepared through freezing-thawing method can not provide the suitable microenvironment for the proliferation of chondrocytes, restricting the application of hydrogels in artificial cartilage. In order to solve this barrier, here, agarose is introduced as porogen to prepare the macroporous PVA hydrogels through freezing-thawing method. The obtained PVA hydrogel have the pore size of 20–200 μm, and macropores have good connectivity. The mechanical properties of the macroporous hydrogels are tested using uniaxial compression and tension experiments and the results show that the mechanical properties of macroporous PVA hydrogels are dependent on the preparation parameters, e.g. the duration of freezing, number of freezing-thawing cycles and the temperature of thawing. After optimization, the mechanical properties of the macroporous PVA hydrogels are closer to those of natural articular cartilage and the obtained hydrogels may be used as the artificial replacement materials.
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