Sustainable agriculture is increasingly constrained by soil degradation, climate variability, and ecological disturbances associated with intensive chemical input use. Plant microbiota — the diverse communities of microorganisms associated with plant tissues and surrounding soil — have emerged as critical regulators of plant growth, productivity, and health. Contemporary research highlights that plant-associated microbial communities function as integral components of plant biology, influencing nutrient acquisition, hormonal regulation, stress tolerance, and immune responses. This review synthesizes recent advances in plant microbiome research, emphasizing mechanistic insights into plant–microbe interactions and their relevance to sustainable crop production. Microbial-mediated processes including nutrient mobilization, phytohormone modulation, abiotic stress resilience, and disease suppression are discussed. Emerging strategies such as microbial inoculants, synthetic microbial consortia, and microbiome engineering are evaluated alongside practical challenges related to microbiome stability, host specificity, and environmental variability.