Small Intestinal Bacterial Overgrowth (SIBO) is increasingly recognized in oncology. It often complicatestreatment, reduces quality of life, and may contribute to carcinogenesis through chronic inflammation.Diagnostic breath tests, widely used for SIBO, show promise in early detection of colorectal polypsand cancer. Current therapies (antibiotics, diet, probiotics) provide partial relief, but data in oncologyremain limited. Recognizing and managing SIBO in cancer care may improve outcomes and requiresfurther research.