Oxidative Cyclization of Active Methylene Amides: Efficient Synthesis of Functionalized 3-Azabicyclo[n.1.0]alkanes

An efficient one-pot method has been developed for the stereoselective synthesis of functionalized 3-azabicyclo[n.1.0]alkanes from N-allyl/homoallyl-malonamates, using CuBr2 as oxidant at room temperature. This method is versatile and provides cyclopropane-fused...