ABSTRACT: In this research, a mathematical model is proposed for predicting wind-induced response of a building with a tuned mass damper (TMD) when soil-structure interaction (SSI) is considered. It may reasonably reflect soil characteristics. Furthermore, TMDs are effective devices for reducing structural vibration. This study may help researchers to more accurately evaluate wind-induced oscillation of high-rise buildings with SSI as well as select appropriate TMDs in controlling structural response.