金丝桃苷
化学
p38丝裂原活化蛋白激酶
骨吸收
细胞生物学
破骨细胞
MAPK/ERK通路
信号转导
药理学
生物化学
生物
内分泌学
体外
抗氧化剂
芦丁
作者
Jun Zhu,Min Zhang,Xiong-Li Liu,Zhigang Yin,X. Han,Huijuan Wang,Ying Zhou
标识
DOI:10.1080/10286020.2022.2056028
摘要
Hyperoside (HP), as a natural product, can promote proliferation and differentiation of osteoblasts and presents a protective effect on ovariectomized (OVX) mice. However, the inhibitory effect of HP on osteoclasts (OCs) and the potential mechanism remain to be elucidated. In this study, it was found that HP could effectively inhibit the differentiation and bone resorption of OCs, and its intrinsic molecular mechanism was related to the inhibition of TRAF6/p38 MAPK signaling pathway. Therefore, HP could be a promising natural compound for lytic bone diseases.
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