弹性蛋白
选择性拼接
细胞生物学
小RNA
RNA剪接
信使核糖核酸
基因表达
转录调控
生物
抄写(语言学)
基因表达调控
基因
核糖核酸
遗传学
语言学
哲学
作者
Sara S. Procknow,Beth A. Kozel
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2022-09-01
卷期号:323 (3): C666-C677
被引量:4
标识
DOI:10.1152/ajpcell.00228.2022
摘要
Elastin provides recoil to tissues that stretch such as the lung, blood vessels, and skin. It is deposited in a brief window starting in the prenatal period and extending to adolescence in vertebrates, and then slowly turns over. Elastin insufficiency is seen in conditions such as Williams-Beuren syndrome and elastin-related supravalvar aortic stenosis, which are associated with a range of vascular and connective tissue manifestations. Regulation of the elastin (ELN) gene occurs at multiple levels including promoter activation/inhibition, mRNA stability, interaction with microRNAs, and alternative splicing. However, these mechanisms are incompletely understood. Better understanding of the processes controlling ELN gene expression may improve medicine's ability to intervene in these rare conditions, as well as to replace age-associated losses by re-initiating elastin production. This review describes what is known about the ELN gene promoter structure, transcriptional regulation by cytokines and transcription factors, and posttranscriptional regulation via mRNA stability and micro-RNA and highlights new approaches that may influence regenerative medicine.
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