Microfiber-associated protein 5 (MFAP5): A promising approach to discover new biomarkers for heart failure and cardiac remodeling

With the increasing aging of the population and the growing incidence of cardiovascular diseases (CVDs) such as hypertension and coronary heart disease, heart failure (HF) is still one of the most important diseases threatening human health and quality of life [ [1] Yu H. Zhang F. Yan P. et al. LARP7 protects against heart failure by enhancing mitochondrial biogenesis. Circulation. 2021; 143: 2007-2022 Crossref PubMed Scopus (22) Google Scholar ]. Cardiac remodeling refers to the adaptive compensatory action of the heart when subjected to various types of stimuli and loads, including cardiac hypertrophy and myocardial fibrosis. When this process is not effectively stopped, it eventually loses compensation and leads to HF [ [2] Wang H.B. Yang J. Shuai W. et al. Deletion of Microfibrillar-associated protein 4 attenuates left ventricular remodeling and dysfunction in heart failure. J. Am. Heart Assoc. 2020; 9e015307 Crossref Scopus (17) Google Scholar ].