脾后皮质
心理学
后扣带
楔前
自传体记忆
大脑活动与冥想
海马体
颞中回
意识的神经相关物
神经活动
额中回
扣带回前部
神经科学
认知心理学
皮质(解剖学)
功能磁共振成像
认知
脑电图
作者
Can Fenerci,Lauri Gurguryan,R. Nathan Spreng,Signy Sheldon
标识
DOI:10.1016/j.neurobiolaging.2022.06.009
摘要
Aging changes autobiographical memory (AM), yet the neural correlates of these changes are poorly understood, likely due to methodological variability across studies. We conducted a quantitative meta-analysis using activation likelihood estimation (GingerALE 3.0.2) to identify regions AM retrieval engaged in younger and older adults across 45 studies (Nyounger = 24 studies, 357 participants, 349 foci; Nolder = 21 studies, 299 participants, 356 foci), considering methodological differences in cueing AMs (i.e., using generic vs. specific/personalized cues). Both age-groups commonly engaged a left-lateralized pattern of brain activity that included the hippocampus, retrosplenial/posterior cingulate cortex, and angular gyrus. Younger adults showed enhanced right posterior cingulate cortical activity, while older adults presented with bilateral activity in the hippocampus, and enhanced activity in left middle temporal gyrus, precuneus, and retrosplenial cortex. Exploratory analyses indicated that age-related commonalties and differences in brain activity depended on the method of AM cuing. These findings suggest that key regions of AM retrieval are preserved in older age, yet subtle changes exist, especially depending on how AMs are cued.
科研通智能强力驱动
Strongly Powered by AbleSci AI