表观遗传学
生物
肠道菌群
组蛋白
寄主(生物学)
遗传学
DNA甲基化
计算生物学
DNA
免疫学
基因表达
基因
作者
Vivienne Woo,Theresa Alenghat
出处
期刊:Gut microbes
[Informa]
日期:2022-01-09
卷期号:14 (1)
被引量:59
标识
DOI:10.1080/19490976.2021.2022407
摘要
The gastrointestinal tract is continuously exposed to trillions of commensal microbes, collectively termed the microbiota, which are environmental stimuli that can direct health and disease within the host. In addition to well-established bacterial sensing pathways, microbial signals are also integrated through epigenetic modifications that calibrate the transcriptional program of host cells without altering the underlying genetic code. Microbiota-sensitive epigenetic changes include modifications to the DNA or histones, as well as regulation of non-coding RNAs. While microbiota-sensitive epigenetic mechanisms have been described in both local intestinal cells and as well in peripheral tissues, further research is required to fully decipher the complex relationship between the host and microbiota. This Review highlights current understandings of epigenetic regulation by gut microbiota and important implications of these findings in guiding therapeutic approaches to prevent or combat diseases driven by impaired microbiota-host interactions.
科研通智能强力驱动
Strongly Powered by AbleSci AI