Deacetylation of Unactivated Amide Bonds in Heterocyclic Systems Using t‐BuOK

Abstract Acetylation is a simple process for the protection of the amine moiety; however, deacetylation of C–N bond cleavage is challenging with use of common reagents. We herein describe the advanced and detailed examples of direct, rapid, and efficient N ‐deacetylation in heterocyclic system using the general inorganic reagent t ‐BuOK at 20 °C. The N ‐acetyl group in the heterocyclic system was cleaved 80% in 10 minutes and the reaction was completed within 30 minutes by using t‐ BuOK.