发色团
立体化学
戒指(化学)
细胞毒性
链霉菌
去肽
苏氨酸
黄色微球菌
化学
金黄色葡萄球菌
生物
细菌
生物化学
体外
丝氨酸
遗传学
有机化学
磷酸化
作者
Miao Dong,Ping Cao,Yue Ma,Jun Luo,Yijun Yan,Rong‐Tao Li,Sheng‐Xiong Huang
标识
DOI:10.1080/14786419.2018.1443097
摘要
Actinomycin Z6 (1), a new member of the actinomycin family, along with three congeners of the Z-type (Z1, Z3, Z5) actinomycins, are produced from Streptomyces sp. KIB-H714. Their structures were authenticated by comprehensive spectroscopic data interpretation. Different from all the reported Z-type actinomycins, the β-ring of the new compound actinomycin Z6 includes an additional ring linked between the actinoyl chromophore and β-peptidolactone. In Z3 and Z5, the L-threonine in β-depsipeptide is replaced by the unusual 4-chlorothreonine, an amino acid rarely found in actinomycin family. All isolates were evaluated for cytotoxicity against five human tumor cell lines and for inhibitory activity against Candida albicans and Staphylococcus aureus.
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