光化学
铱
磷光
单线态氧
系统间交叉
费斯特共振能量转移
紧身衣
光漂白
荧光
猝灭(荧光)
光动力疗法
纳米颗粒
材料科学
聚合物
化学
共轭体系
单重态
纳米技术
氧气
有机化学
激发态
催化作用
核物理学
物理
量子力学
作者
Jun Jiang,Yuanyuan Qian,Zihan Xu,Zhuang Lv,Ping Tao,Mingyuan Xie,Shujuan Liu,Wei Huang,Qiang Zhao
出处
期刊:Chemical Science
[The Royal Society of Chemistry]
日期:2019-01-01
卷期号:10 (19): 5085-5094
被引量:61
摘要
Photosensitizers (PSs) are of particular importance for efficient photodynamic therapy (PDT). Challenges for PSs simultaneously possessing strong light-absorbing ability, high 1O2 generation by effective intersystem crossing from the singlet to the triplet state, good water-solubility and excellent photostability still exist. Reported here are a new kind of dual-emissive semiconducting polymer nanoparticles (SPNs) containing fluorescent BODIPY derivatives and near-infrared (NIR) phosphorescent iridium(iii) complexes. In the SPNs, the BODIPY units serve as the energy donors in the fluorescence resonance energy transfer (FRET) process for enhancing the light absorption of the SPNs. The NIR emissive iridium(iii) complexes are chosen as the energy acceptors and efficient photosensitizers. The ionized semiconducting polymers can easily self-assemble to form hydrophilic nanoparticles and homogeneously disperse in aqueous solution. Meanwhile, the conjugated backbone of SPNs provides effective shielding for the two luminophores from photobleaching. Thus, an excellent overall performance of the SPN-based PSs has been realized and the high 1O2 yield (0.97) resulting from the synergistic effect of BODIPY units and iridium(iii) complexes through the FRET process is among the best reported for PSs. In addition, owing to the phosphorescence quenching of iridium(iii) complexes caused by 3O2, the SPNs can also be utilized for O2 mapping in vitro and in vivo, which assists in the evaluation of the PDT process and provides important instructions in early-stage cancer diagnosis.
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