芴
化学
烷基化
反应性(心理学)
衍生工具(金融)
乙腈
有机化学
高分子化学
药物化学
聚合物
催化作用
医学
金融经济学
病理
经济
替代医学
作者
John Perumattam,Charley Shao,William L. Confer
出处
期刊:Synthesis
[Georg Thieme Verlag KG]
日期:1994-01-01
卷期号:1994 (11): 1181-1184
被引量:10
摘要
Efficient large-scale syntheses of 9-(2-hydroxyethyl)fluorene (1) and its 2,7-dichloro derivative 2 are described. Major differences exist in the reactivity of fluorene and its 2,7-dichloro derivative toward 9-alkylation. These differences are attributed to the difference in acidity of the protons in the 9-position of these compounds. Also 2,7-dichlorination of fluorene and its derivatives was satisfactorily achieved by treatment with NCS and conc. HCl in acetonitrile under carefully controlled conditions. Specifically, a highly concentrated solution of substrates and elevated temperatures were required for facile 2,7-dichlorination.
科研通智能强力驱动
Strongly Powered by AbleSci AI