粒体自噬
细胞生物学
线粒体
线粒体分裂
线粒体融合
生物
生物发生
细胞器
自噬
化学
生物化学
线粒体DNA
基因
细胞凋亡
作者
Seung‐Min Yoo,Yong‐Keun Jung
出处
期刊:PubMed
日期:2018-01-31
卷期号:41 (1): 18-26
被引量:209
标识
DOI:10.14348/molcells.2018.2277
摘要
Mitochondrial quality control systems are essential for the maintenance of functional mitochondria. At the organelle level, they include mitochondrial biogenesis, fusion and fission, to compensate for mitochondrial function, and mitophagy, for degrading damaged mitochondria. Specifically, in mitophagy, the target mitochondria are recognized by the autophagosomes and delivered to the lysosome for degradation. In this review, we describe the mechanisms of mitophagy and the factors that play an important role in this process. In particular, we focus on the roles of mitophagy adapters and receptors in the recognition of damaged mitochondria by autophagosomes. In addition, we also address a functional association of mitophagy with mitochondrial dynamics through the interaction of mitophagy adaptor and receptor proteins with mitochondrial fusion and fission proteins.
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