细胞凋亡
激酶
蛋白激酶B
细胞毒性
体内
磷脂酰肌醇
细胞生物学
体外
生物相容性
化学
癌症研究
PI3K/AKT/mTOR通路
材料科学
生物化学
生物
生物技术
有机化学
作者
Huan Zhao,Chengheng Wu,Dongwen Gao,Suping Chen,Yuda Zhu,Jing Sun,Hongrong Luo,Kui Yu,Hongsong Fan,Xingdong Zhang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2018-07-30
卷期号:12 (8): 7838-7854
被引量:76
标识
DOI:10.1021/acsnano.8b01996
摘要
Hydroxyapatite nanoparticles (HA NPs) have been acknowledged for their benign biocompatibility and proliferation inhibition effect on tumor cells, attracting considerable attention for tumor therapeutics without late effects. However, unnoticeable tumor cytotoxicity of HA NPs limited the final clinical therapeutic efficacy. Herein, a two-phase synthetic approach was developed to synthesize sphere-like HA NPs by varying the conventional growth habit of HA precipitate. We present our in vitro and in vivo experimental evidence that spherical HA NPs have surprisingly high inhibitory activities against tumor cells. We demonstrate further, based on our experimental data, that the underlying cause for the death of the tumor cells is related to two concurrent pathways, the mitochondria-dependent apoptosis pathway and negative regulation of the phosphatidylinositol-3-kinase/protein kinase B (PIK3/AKT) pathway. The present study indicated that HA nanospheres can be engineered as nontoxic specific inhibitors for efficient tumor therapeutics with nanobiomaterials.
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