生物粘附
壳聚糖
粒径
纳米颗粒
Zeta电位
药物输送
分散性
离子强度
材料科学
生物利用度
化学
色谱法
化学工程
纳米技术
药理学
有机化学
水溶液
医学
物理化学
工程类
作者
Vivekjot Brar,Gurpreet Kaur
出处
期刊:Pharmaceutical nanotechnology
[Bentham Science]
日期:2018-12-18
卷期号:6 (3): 180-191
被引量:3
标识
DOI:10.2174/2211738506666180813122437
摘要
To prepare chitosan-okra gum nanoparticles and their evaluation as mucoadhesive drug delivery system for intranasal delivery of esculin.Esculin loaded chitosan-okra gum based nanoparticles were prepared using ionic gelation method. The preparation method was optimized using Box-Behnken experimental design employing okra gum concentration, chitosan concentration, pH and stirring speed as independent variables and particle size, encapsulation efficiency and zeta potential of the formulation were selected as dependent variables. The optimized formulation was characterized using FTIR, SEM and TEM. The nanoparticles were evaluated for their bioadhesive strength and in vitro drug release studies. The optimized intranasal formulation was administered to rats and the pharmacokinetic profile and biodistribution studies were carried out to calculate the targeting efficiency of the formulation in the brain.The nanoparticles were found to depict particle size in the range of 294.0 to 613.4 nm. The concentration of gums was found to significantly influence the particle size and encapsulation efficiency. The nanoparticles depicted bioadhesive strength of 32±2%. The in vitro drug release studies showed 96.4±4.2% release of esculin from nanoparticles in 4h. The drug targeting of NPs to brain was found to be nearly double that of esculin given as simple solution.The nanoparticles prepared using chitosan-okra gum were found to possess good mucoadhesive strength with and high brain targeting efficiency.
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