活性氧
氧化应激
缺血
氧气
再灌注损伤
激进的
细胞凋亡
药理学
化学
肝损伤
医学
生物化学
内科学
有机化学
作者
Dong Chen,Chaoqun Wang,Hongjun Yu,Guanxiong Liu,Bo Qian,Bangliang Chen,Zhongyu Li,Yongzhi Zhou,Shangha Pan,Baoqiang Li,Yong Ma
出处
期刊:ACS applied nano materials
[American Chemical Society]
日期:2023-07-11
卷期号:6 (14): 13155-13165
被引量:3
标识
DOI:10.1021/acsanm.3c01885
摘要
Hepatic ischemia–reperfusion injury (HIRI), which is a common pathophysiological process that occurs in hepatectomy, affects the survival and prognosis of patients. In this study, we synthesized chitosan-derived nitrogen-doped carbon dots (CNDs) with reactive oxygen species (ROS) scavenging capabilities and applied them in the prevention of HIRI. CNDs demonstrated scavenging ability against ROS, particularly hydroxyl radicals. Our results show that CNDs can alleviate liver damage in mice, suppress the inflammatory response, and inhibit apoptosis triggered by liver ischemia/reperfusion (I/R) operation. Mechanistically, CNDs exhibit hepatoprotective effects on I/R injury due to the clearance of ROS. In summary, CNDs protect the liver against ischemia–reperfusion injury by suppressing oxidative stress damage.
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