优势比
认知
逻辑回归
内科学
前瞻性队列研究
血压
认知障碍
医学
心理学
心脏病学
神经科学
作者
Huijing Shi,Liufu Cui,Ying Hui,Anxin Wang,Xiaoshuai Li,Rong Shu,Hongxin Song,Jierui Wang,Peiwu Yu,Shuohua Chen,Jing Li,Lu Yang,Zhenchang Wang,Qing Yang,Yuxia Gao
出处
期刊:Hypertension
[Ovid Technologies (Wolters Kluwer)]
日期:2023-10-01
卷期号:80 (10): 2088-2098
被引量:2
标识
DOI:10.1161/hypertensionaha.123.21453
摘要
Hypertension and enlarged perivascular spaces (EPVS) are thought to be associated with cognitive impairment. However, the correlations among hypertension, EPVS, and cognitive impairment have not been studied yet. We aimed to investigate the relationships between cumulative blood pressure (cBP) exposure with EPVS and cognitive impairment and whether EPVS may mediate the relationship between cBP and cognitive impairment.A total of 1507 subjects from the Kailuan prospective cohort study were enrolled. cBP was calculated from 2006 to 2022. The effects of cBP, EPVS scores, and cognitive impairment were evaluated using a logistic regression model. The relationships among cBP, EPVS score, and cognitive impairment were analyzed using a mediation model.An increase in cBP was positively correlated with an increase in EPVS score. For every SD increase in cBP, the odds ratios (95% CI) of increased EPVS score of the centrum semiovale were 1.67 (1.43-1.95), 1.63 (1.4-1.9), and 1.35 (1.17-1.56), respectively; the odds ratios (95% CI) of increased EPVS score of the basal ganglia were 1.83 (1.56-2.15), 2.01 (1.7-2.36), and 1.31 (1.13-1.52), respectively; and the odds ratios (95% CI) of developing cognitive impairment were 1.28 (1.06-1.53), 1.13 (0.95-1.34), and 1.28 (1.07-1.5), respectively. Basal ganglia-EPVS score accounted for 10.46% to 18.32% of the mediating effects on the relationships of cBP/SD with cognitive impairment.High cBP exposure was an independent risk factor for EPVS, and basal ganglia-EPVS score mediated the effects of cBP on cognitive impairment.URL: https://www.gov; Unique identifier: ChiCTR-TNRC-11001489.
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