骨质疏松症
Wnt信号通路
超分子化学
骨形成
化学
人口
医学
药理学
纳米技术
内分泌学
材料科学
生物化学
信号转导
有机化学
分子
环境卫生
作者
Zhuang-Peng Chang,Dengke Chen,Junsong Peng,Rongyan Liu,Beibei Li,J.H. Kang,Li Xin Guo,Rujing Hou,Xianghui Xu,Min Lee,Xiao Zhang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2024-04-11
被引量:1
标识
DOI:10.1021/acs.nanolett.4c00029
摘要
Developing novel strategies for defeating osteoporosis has become a world-wide challenge with the aging of the population. In this work, novel supramolecular nanoagonists (NAs), constructed from alkaloids and phenolic acids, emerge as a carrier-free nanotherapy for efficacious osteoporosis treatment. These precision nanoagonists are formed through the self-assembly of berberine (BER) and chlorogenic acid (CGA), utilizing noncovalent electrostatic, π–π, and hydrophobic interactions. This assembly results in a 100% drug loading capacity and stable nanostructure. Furthermore, the resulting weights and proportions of CGA and BER within the NAs are meticulously controlled with strong consistency when the CGA/BER assembly feed ratio is altered from 1:1 to 1:4. As anticipated, our NAs themselves could passively target osteoporotic bone tissues following prolonged blood circulation, modulate Wnt signaling, regulate osteogenic differentiation, and ameliorate bone loss in ovariectomy-induced osteoporotic mice. We hope this work will open a new strategy to design efficient herbal-derived Wnt NAs for dealing with intractable osteoporosis.
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