药物输送
药品
前药
纳米技术
生物医学工程
计算机科学
医学
材料科学
药理学
作者
Param Jot,Sheetu Wadhwa,Pardeep Kumar Sharma,Sachin Kumar Singh,Sukriti Vishwas,Rajnish Kumar,S. K. Singh,Kamal Dua,Dinesh Kumar Chellappan,Gaurav Gupta
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2024-01-01
卷期号:21 (1): 16-37
标识
DOI:10.2174/1567201820666230110140312
摘要
Amongst different routes of drug delivery systems, ophthalmic drug delivery still requires a careful investigation and strict parameter measurements because the eyes are one of the most sensitive parts of the body and require special attention. The conventional systems for eyes lead to rapid elimination of formulation and hence very small contact time on the ocular epithelium. The current review article covers various types of polymers used in ocular drug delivery along with their applications/ limitations. Polymers are widely used by researchers in prodrug techniques and as a penetration enhancer in ocular delivery. This article covers the role and use of different polymeric systems which makes the final formulation a promising candidate for ophthalmic drug delivery. The researchers are still facing multiple challenges in order to maintain the therapeutic concentration of the drug in the eyes because of its complex structure. There are several barriers that further restrict the intraocular entry of the drug. In order to remove/reduce such challenges, these days various types of polymers are used for ocular delivery in order to develop different drug carrier systems for better efficacy and stability. The polymers used are highly helpful in increasing residence time by increasing the viscosity at the ocular epithelium layer. Such preparations also get easily permeated in ocular cells. The combination of different polymeric properties makes the final formulation stable with prolonged retention, high viscosity, high permeability, and better bioavailability, making the final formulation a promising candidate for ocular drug delivery.
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