氧化应激
尼古丁
炎症
吸入
肝损伤
药理学
化学
毒性
香烟烟雾
医学
内科学
内分泌学
毒理
麻醉
生物
作者
Yushan Tian,Hongjuan Wang,Shulei Han,Yaning Fu,Fengjun Lu,Wenming Wang,Xianmei Li,Shuhao Ma,Pengxia Feng,Zhi‐Hao Shi,Huan Chen,Hongwei Hou
出处
期刊:Toxicology Research
[Oxford University Press]
日期:2024-01-01
卷期号:13 (1)
标识
DOI:10.1093/toxres/tfae002
摘要
Heated tobacco product (HTP) considered to be a novel tobacco product which was reported safer than traditional cigarettes evidenced by lower potential harmful components released. Liver is an important detoxification organ of the body, the chemical components in aerosols are metabolized in the liver after absorbed, so it is necessary to explore the effect of HTP on the liver.The potential effect of HTP and cigarette smoke (CS) on SD rats was explored according to OECD 413 subchronic inhalation. The rats were randomly divided into Sham (air), different dosage of HTP groups (HTP_10, 23 and 50 μg nicotine/L aerosol) and Cig_23 (23 μg nicotine/L aerosol) group. After exposure, the clinical pathology, inflammation and oxidative stress were measured.The clinical pathology results showed that both HTP_50 and Cig_23 led to abnormality of ALT for male rats. CS and HTP exposure reduced the expression of IL-1β, IL-6 and TNF-α and mitochondrial medicated oxidative stress. In addition, the ATP production was reduced in Cig_23 group. Although inflammation and oxidative stress were displayed, no apoptosis were observed by TUNEL assay and these existed obvious pathological changes only in HTP_50 group, while in CS group with equivalent nicotine, hepatocytes swelling were observed in liver.CS exposure induced liver damage through mitochondrial mediated oxidative stress and inflammation, which was also observed in high concentration of HTP exposure group. For the same equivalent nicotine, HTP may show lower toxic effect on liver than CS.
科研通智能强力驱动
Strongly Powered by AbleSci AI