PSA Density and Lesion Volume: Key Factors in Avoiding Unnecessary Biopsies for PI‐RADS 3 Lesions

ABSTRACT Introduction The use of multiparametric magnetic resonance imaging (MRI) to guide prostate biopsies has improved cancer detection rates, particularly for high‐grade tumors. However, despite guidelines recommending biopsies for lesions with a Prostate Imaging‐Reporting and Data System (PI‐RADS) score ≥ 3, the clinical significance of PI‐RADS 3 lesions remains uncertain. This uncertainty, coupled with the cost and potential complications of biopsies, underscores the need for more accurate risk stratification strategies to avoid unnecessary procedures. Prostate‐specific antigen density (PSAD) and index lesion volume are emerging as potential contributors to improve risk assessment. Materials and Methods This was a retrospective analysis of patients who had undergone an MRI‐guided transrectal ultrasound (TRUS) prostate biopsy at a tertiary care institution. Patients with PI‐RADS 3 lesions were included, and data on demographics, prostate‐specific antigens (PSA), PSAD, lesion diameter, and pathology results were collected. The relationships between PSAD, lesion volume, and pathology outcomes were statistically analyzed. Results Of the 213 patients included, 40 were diagnosed with prostate cancer. PSAD and PSAD x lesion diameter were significantly higher in the patients diagnosed with prostate cancer than those with benign lesions. Among the prostate cancer patients, clinically significant prostate cancer (csPCa) had a higher mean PSAD value than clinically insignificant prostate cancer (cisPCa). ROC analysis found PSAD x lesion diameter to have the highest discriminatory power for detecting csPCa. Discussion MRI‐guided biopsies offer targeted sampling but the clinical significance of PI‐RADS 3 lesions remains uncertain. Index lesion volume and PSAD are promising adjunctive markers for risk assessment. Combining these factors could facilitate the avoidance of unnecessary biopsies and improve the detection of csPCa. Conclusion Incorporating PSAD and index lesion volume into biopsy decision‐making may enhance risk stratification, particularly for PI‐RADS 3 lesions. Further research is needed to validate these findings and enhance the risk assessment strategies used in making decisions regarding prostate biopsy.